To address the role of free thiols in males of couples seeking infertility treatment.
ID
Source
Brief title
Condition
- Reproductive tract disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameter will be free thiols in patients with
oligo-asthenospermia and patients with normospermia.
Secondary outcome
Concomitant measurable antioxidants.
General health parameters:
- BMI
- Comorbidities
- Medication
- Level of degree
Lifestyle parameters:
- Diet
- Physical activity
- Smoking
- Illicit drug use
- Toxic exposure at work
Background summary
Human cells use oxygen to survive and thus produce free radicals (FR).
Oxidative stress (OS) occurs when reactive oxygen species (ROS) production
exceeds the cell damage defense system. Elevated ROS levels, due to various
endogenous and exogenous factors are associated with a reduced fertilizing
capacity of spermatozoa.
Free thiols are readily oxidized by oxygen and sulfur species and their
circulating level may directly reflect the systemic redox status. In males with
oligo-asthenospermia it is thought that the systemic redox status is different
compared to males with a normospermia. This might be of interest regarding a
potential target for therapy.
Study objective
To address the role of free thiols in males of couples seeking infertility
treatment.
Study design
Exploratory cross-sectional pilot study.
Study burden and risks
There will be no direct benefit for the participating males, other than the
perspective of the feeling to contribute to extending the knowledge on male
infertility. After informed consent a questionnaire will be taken by telephone
and a single blood sample will be withdrawn on the day of semen analysis,
preventing an extra visit to the hospital.
hanzeplein 1
Groningen 9713RB
NL
hanzeplein 1
Groningen 9713RB
NL
Listed location countries
Age
Inclusion criteria
In order to be eligible to participate in this study, a subject must meet all
of the following criteria:
males of couples visiting the Center of Reproductive medicine at the UMCG
between 18-55 years old.
Exclusion criteria
* Males who receive(d) chemo- and/or radiotherapy, use(d) testosterone
suppletion and/or anabolic steroids
* Males who have an abnormal SA due to genetic causes.
* Semen analysis with round cells >2x106 /ml (as marker for infection)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL75634.042.20 |