The aim of the project is to further develop and evaluate skin disease models by investigating the synthesis and cytokine release in atopic dermatitis lesions. This information can establish the right formulation of new medicines for further in…
ID
Source
Brief title
Condition
- Epidermal and dermal conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Cytokine synthesis and release.
Secondary outcome
-
Background summary
Atopic dermatitis is an immune-mediated disease in which proinflammatory
protein mediators, released by skin cells/infiltrating cells, and a defect in
the stratum corneum are intrinsic to the characteristics of the disease. It may
be possible to treat atopic dermatitis using drugs aimed at preventing the
synthesis of such mediators.
Study objective
The aim of the project is to further develop and evaluate skin disease models
by investigating the synthesis and cytokine release in atopic dermatitis
lesions. This information can establish the right formulation of new medicines
for further in vitro/ in vivo research. This research also contributes to the
reduction, refinement, and/or replacement of laboratory animal*s use.
Study design
Skin biopsies of 3 mm in diameter will be treated in vitro with test compounds
and the proper controls. By measuring the effect on the cytokine synthesis and
release, it is possible to establish the right formulation and dose of
potential test compounds for further research.
Study burden and risks
The health risks associated with taking skin biopsies are small. It is possible
to obtain a slight scar formation and/or discolouration at the site of the
biopsy punch.
Wytemaweg 80
Rotterdam 3015 CN
NL
Wytemaweg 80
Rotterdam 3015 CN
NL
Listed location countries
Age
Inclusion criteria
Patients with moderate to severe atopic dermatitis
Exclusion criteria
Volunteers undergoing UV/light therapy or taking systemic drugs such as cyclosporin A or methotrexate
Volunteers using local topical corticosteroids
Volunteers developing Köbner phenomenon at wound sites
Design
Recruitment
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL60971.098.17 |