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The main objective of this study is to investigate the effectiveness of BEAR (a parent training combining e-learning and home visits) compared to care-as-usual (CAU) in young children (12-30 months) who are at risk of developing ASD, in a cluster…
(1) The stand-alone treatment of sleep problems will have a clinically significant effect on the reduction of ADHD symptoms in adults with ADHD. (2) The concurrent treatment of sleep problems and usual care is more effective than usual care to treat…
Mechanical bowel preparation (MBP) is common practice in elective colorectal surgery. In recent literature the value of MBP is subject of discussion. This non-inferiority, randomized study evaluates the value of MBP before colorectal surgery.
We hypothesize that implementation of the new post-transplantation program will result in: - Decreased renal function decline (improved graft survival) - Improved medication adherence - Improved tacrolimus exposition - Improved feeling of patient…
The hypothesis to be tested is that the outcome in arm B is better than in arm A.
Drug-induced Sleep Endoscopy with cocomittant jaw thrust maneuver is a suitable predictor for succes of oral appliance treatment.
The combination of breast surgery, radiotherapy and chemotherapy have a profound effect on the deep myofascial level and in turn, they create a vicious circle of adhesions and lack of mobility and pain in muscles, fasciae and joints around the…
It is hypothesized that the E-health self-management treatment results in lower impact of the disease on daily life, primarily a lower level of distress, in comparison to care as usual. As secondary objectives the effectiveness of the treatment on 4…
The aim of this study is to investigate whether the optical tissue stylet technology can discriminate tissues that are relevant for interventional pain procedures.
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We aim to test the hypotheses that offering additional online adaptive coaching to a web-based self-management program will be more effective than a web-based self-management program without coaching in terms of self-management behaviour without…
The aim of this study is to investigate the non-inferiority of perioperative continuation of aspirin patients undergoing spinal surgery, compared with the current policy of perioperative discontinuation of aspirin.
We hypothesize that a treatment algorithm that is based on a simple validated measure of health status (CCQ) improves quality of life (as measured on a separate scale) and other classical COPD outcome measurement parameters such as exacerbation…
A constant Hb concentration will improve the quality of life of patiënts with a chronic need for bloodtransfusions.
Structural imaging is more sensitive to early (progression) detection than functional measurements (i.e. visual fields).
Computer-tailored safety information combined with personal counseling results in: 1. Improved parents¡¦ child safety behaviors; 2. Improved satisfaction with different elements of intervention.
We hypothesize that use of the shortened MRI protocol instead of ultrasound in the postoperative surveillance will reduce the risk of and extend the time to possible recurrent liver metastasis.
What is the effect of carbohydrate infusion on food choice, food intake, satiety, hormones, dependent on the time of day and segment of the small intestine?
Interferons (IFNs) are a family of cytokines which have important antiviral and antiproliferative properties. They also play an important role in immunomodulation. Type I IFNs have been implicated in autoimmune diseases, including systemic lupus…
The primary research hypotheses are: 1. Patients who follow the Onco-Move program will achieve better physical fitness levels, as assessed by objective performance tests, and will report less fatigue than patients in the usual care control group; 2…